師資隊伍 |
白凈衛(wèi), PhD

白凈衛(wèi)

研究員，博士生導(dǎo)師

白凈衛(wèi)博士本科就讀北京大學(xué)化學(xué)系，2011年6月畢業(yè)于美國加州大學(xué)洛杉磯分校獲材料學(xué)博士學(xué)位。 2011.6-2013.6，在IBM 沃森實驗室從事博士后研究，后受聘于美國基因測序技術(shù)公司Illumina Inc. 從事研發(fā)工作。2016加入清華大學(xué)藥學(xué)院任特聘研究員，博士生導(dǎo)師。攻讀博士期間結(jié)合前沿半導(dǎo)體工藝完成了石墨烯納米篩結(jié)構(gòu)和超高頻石墨烯射頻晶體管等原創(chuàng)性科研成果，為石墨烯電子器件領(lǐng)域進(jìn)展做出了突出貢獻(xiàn)。博后期間在IBM前沿半導(dǎo)體制成技術(shù)的基礎(chǔ)上拓展納米制備技術(shù)在單分子生物傳感器方面的應(yīng)用，領(lǐng)導(dǎo)了基于“Top down”技術(shù)路線制備固態(tài)納米孔的研究工作。之后加入了基因測序技術(shù)領(lǐng)域處于世界領(lǐng)先地位的Illumina Inc.，負(fù)責(zé)研發(fā)基于納米孔構(gòu)造和納米線晶體管原理的新一代基因測序技術(shù)。已獲得授權(quán)十余項項。在Nature、Nature Nanotechnology，Nano Letters, PNAS等期刊上發(fā)表論文三十余篇。回到清華大學(xué)藥學(xué)院至今作為課題負(fù)責(zé)人已獲得三項科技部重點項目資助，領(lǐng)導(dǎo)基于納米孔的新一代基因測序技術(shù)的研發(fā)。

研究方向:

新一代DNA測序技術(shù)是基于單分子連續(xù)測序的策略，針對于核酸分子鏈上的堿基序列進(jìn)行逐個快速識別和測定。而基于納米孔技術(shù)的第四代測序技術(shù)可直接對DNA、RNA分子進(jìn)行直接測序，測序片段可到數(shù)萬以上堿基、儀器尺寸小、測序速度快、文庫制備簡單等優(yōu)勢，在優(yōu)化現(xiàn)有測序結(jié)果和拓展測序技術(shù)應(yīng)用領(lǐng)域方面形成“互補(bǔ)”，在病原體微生物監(jiān)測、基因組結(jié)構(gòu)變異、表觀遺傳修飾、蛋白測序等方面具有十分重要的應(yīng)用前景。
本課題組主要研究基于納米孔測序平臺的底層技術(shù)開發(fā)，以及單分子長度長測序技術(shù)的臨床應(yīng)用研究：

1) 納米孔測序核心技術(shù)：主要研究核心納米孔蛋白的進(jìn)化和單分子控速策略。通過復(fù)合的生物大分子動力蛋白，研究核酸、多肽、多糖等線性生物分子在納米孔中的移動和相互作用，開發(fā)新型納米孔測序方法和蛋白互作檢測技術(shù)。

2) 高通量長度長測序技術(shù)的臨床應(yīng)用：主要研究適應(yīng)于納米孔長度長測序的建庫方法，應(yīng)用于單細(xì)胞基因組長度長測序、快速靶向建庫、cfDNA的高通量測序建庫、快速去宿主核酸的宏基因組測序技術(shù)。

3) Point-of-Care核酸檢測技術(shù)：開發(fā)高靈敏度快速核酸等溫擴(kuò)增方法和肉眼可見的顯色技術(shù)，實現(xiàn)不依賴復(fù)雜儀器的快速現(xiàn)場高靈敏度病原體快檢。
 

榮譽(yù)和獎勵:

IBM First Plateau Invention Achievement Award, IBM T J Watson Research, 2013年
Harry M. Showman Prize, University of California, Los Angeles 2011年
Graduate Student Silver Award, Material Research Society (MRS) Fall Meeting 2010年

 代表論文:

1.     B. Wang, Y. Sun, H. Ding, X. Zhao, L. Zhang, J.W.Bai*, K. Liu*, “Bioelectronics-Related 2D Materials Beyond Graphene: Fundamentals, Properties, and Applications”，Advanced Functional Materials (2020), 2003732.
2.     R.Tian*, Y. Li, J.W.Bai*, “Hierarchical assembled nanomaterial paper based analytical devices for simultaneously electrochemical detection of microRNAs”， Analytica Chimica Acta (2019), 1058, 89.
3.     R. Tian, W. Ning, M. Chen, C. Zhang, Q. Li*, J.W.Bai*, “High performance electrochemical biosensor based on 3D nitrogen-doped reduced graphene oxide electrode and tetrahedra DNA nanostructure”， Talanta (2019), 194, 273.
4.     J. W.  Bai?, D. Wang?, S.W. Nam, H. Peng, R. Bruce, L. Gignac, M. Brink, E. Kratschmer, S. Rossnagel, P. Waggoner, K. Reuter, C. Wang, Y. Astier, V. Balagurusamy, B. Luan, Y. Kwark , E. Joseph, M. Guillorn, S. Polonsky, A. Royyuru, S. Papa Rao, G. Stolovitzky, “Fabrication of sub-20nm nanopore arrays in membranes with embedded metal electrodes at wafer scales”, Nanoscale (2014), 6, 8900.
5.     R. Cheng?, J. W.  Bai? (Co-author with Equal contribution), L. Liao, H. Zhou, Y. Chen, L. Liu, Y.-C. Lin, S. Jiang, Y. Huang, X. F. Duan, “High-frequency self-aligned graphene transistors with transferred gate stacks”, Proceedings of the National Academy of Sciences of The United States of America (2012), 109, 11588.  
6.     J. W.  Bai, L. Liao, H. Zhou, R. Chen, L. Liu, Y. Huang, X. F. Duan, “Top-gated chemical vapor deposition grown graphene transistors with current saturation”, Nano Letters (2011) 11, 2555. 
7.     J. W.  Bai, Y. Huang, “Fabrication and electrical properties of graphene nanoribbons”, Materials Science and Engineering: R (2010) 70, 341. Invited Review 
8.     J. W.  Bai?, R. Cheng?, F. X. Xiu, L. Liao, M. S. Wang, A. Shailos, K. L. Wang, Y. Huang, X. F. Duan, “Very large magnetoresistance in graphene nanoribbons”, Nature Nanotechnology (2010) 5, 655. 
9.     J. W.  Bai, X. Zhong, S. Jiang, Y. Huang, X. F. Duan, “Graphene nanomesh”, Nature Nanotechnology (2010) 5, 190. 
10.     J. W.  Bai, X. F. Duan, Y. Huang, “Rational fabrication of graphene nanoribbons with nanowire etch mask”, Nano Letters (2009) 9, 2083.
11.     J. W. Bai, S. Huang, L. Wang, Y. Chen, Y. Huang, “Fluid assisted assembly of one-dimensional nanoparticle array inside inorganic nanotubes”, Journal of Materials Chemistry (2009) 19, 921. 
12.     J. W. Bai, Y. Qin, C. Jiang, L. M. Qi, “Polymer-controlled synthesis of silver nanobelts and hierarchical nanocolumns”, Chemistry of Materials (2007) 19, 3367.
13.     P. Pang, B. Ashcroft, W. Song, P. Zhang, S. Biswas, Q. Qing, J. Yang, R. Nemanich, J. W. Bai, J. Smith, K. Reuter, V. Balagurusamy, Y. Astier, G. Stolovitzky, S. Lindsay, “Fixed-gap Tunnel Junction for Reading DNA Nucleotides”, ACS Nano (2014), 8, 11994. 
14.     B. Luan, J. W. Bai, G. Stolovitzky, “Fabricatable nanopore sensors with an atomic thickness”, Applied Physics Letters (2013), 103, 183501. 
15.     L. Liao, J. W. Bai, R. Cheng, H. L. Zhou, L. X. Liu, Y. Liu, Y. Huang, X. F. Duan, “Scalable fabrication of self-aligned graphene transistors and circuits on glass”, Nano Letters (2012), 12, 2653. 
16.     Z. Zhong, H. Zhang, Y. Liu, J. W. Bai, L. Liao, Y. Huang, X. F. Duan, “High-capacity silicon-air battery in alkaline solution”, Chemsuschem (2012), 5, 177. L. Liu, H. Zhou, R. Cheng, Y. Chen, Y.-C. Lin, Y. Qu, J. W. Bai, I. A. Ivanov, G. Liu, Y. Huang, X. F. Duan, “A systematic study of atmospheric pressure chemical vapor deposition growth of large area monolayer graphene”, Journal of Materials Chemistry (2012), 22, 1498. 
17.     Y. Liu, R. Cheng, L. Liao, H. Zhou, J. W. Bai, G. Liu, L. Liu, Y. Huang, X. F. Duan, “Plasmon resonance enhanced multicolour photodetection by graphene”, Nature Communication (2011), 2, 579. 
18.     G. Xu, C. M. Torres, J. W. Bai, J. Tang, T. Yu, Y. Huang, X. F. Duan, Y. Zhang, K. L. Wang, “Linewidth roughness in nanowire-mask-based graphene nanoribbons”, Applied Physics Letters (2011), 98, 243118. 
19.     Y. Qu, J. W. Bai, L. Liao, R. Cheng, Y.C. Lin, Y. Huang, T. Guo, X. F. Duan, “Synthesis and electric properties of dicobalt silicide nanobelts”, Chemical Communications  (2011), 47, 1255.
20.     G. Xu, C. M. Torres, J. Tang, J. W.  Bai, E. Song, Y. Huang, X. F. Duan, Y. Zhang, K. L. Wang, “Edge effect on resistance scaling rules in graphene nanostructures”, Nano Letters (2011) 11, 1082. 
21.     L. Liao, Y. C. Lin, M. Bao, R. Cheng, J. W. Bai, Y. Liu, K. L. Wang, Y. Huang, X. F. Duan, “High speed graphene transistor with a self-aligned nanowire gate”, Nature (2010) 467, 305.

    部分專利    
 

  1. 中國專利 一種形成薄膜的方法和應(yīng)用，2021，CN109338598B；

  2. 美國專利Compositions and methods for single molecular placement on a substrate，2019，US10350570B；

  3. 美國專利 Hybrid Nanopore Sensors，2019，US10519499B；

  4. 美國專利 Bichemically activated electronic device, 2020, US10545115B；

  5. 美國專利 Methods and arrays for producing and sequencing monoclonal clusters of nucleic acid, 2020, US10619204B。

聯(lián)系方式:

 
郵件：     jingwbai@mail.tsinghua.edu.cn;    
電話：010-62789815；    
地址：清華大學(xué)生物技術(shù)館3-209
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