1. 氮雜環(huán)卡賓有機不對稱催化對醛實現(xiàn)多位點、選擇性的官能化：以廉價易得的醛為基礎化工原料，實現(xiàn)多位點、選擇性的官能化是構筑新穎手性片段最直接、高效的方法之一。同時這些片段是各種高附加值化學產品或藥物的前體，具有重要的商業(yè)價值。申請人通過改造卡賓催化劑立體結構和電子效應來調控反應的化學、區(qū)域、以及立體選擇性；通過引入協(xié)同催化策略和發(fā)展合適的親電或親核試劑來優(yōu)化反應的活化能,最終在醛的多個位置(鄰位、間位、遠端的碳)實現(xiàn)了不對稱氟化、氫酰化、中環(huán)化、芳構化等官能團化反應。重點突破了對富電子烯烴加成難得瓶頸,填補了卡賓高效、多樣性催化合成光學活性寡糖得空白; 發(fā)展了卡賓與路易斯酸或布朗斯特酸催化協(xié)同策略，為“卡賓催化實現(xiàn)遠程立體控制”提供了解決思

路。 

 

2. 金屬參與的碳氫鍵催化活化實現(xiàn)雜環(huán)的高效合成：提出了基于金屬插入碳氫鍵活化的方式，結合炔作為搭建砌塊，高區(qū)域選擇性的合成了一些重要的雜環(huán)骨架，為多樣性合成基于該類優(yōu)勢核心結構的先導化合物或雜環(huán)碎片提供了重要方法依據(jù)。

3. 通過高通量篩選，并對所發(fā)現(xiàn)的先導化合物進行改造，成功了發(fā)現(xiàn)了能夠誘導胚胎干細胞定向分化和控制造血干細胞體外擴增的Lead小分子。該兩個項目已經分別進入了不同的臨床實驗階段，將對干細胞再生藥物的研究起到重要推動作用。

4．基于“遺忘機制”開發(fā)治療老年癡呆癥新藥：申請人團隊與清華大學生命學院腦科學專家鐘毅教授團隊聯(lián)合，結合多年對研究大腦所獲得的深入理解，另辟蹊徑，以遺忘機制作為研發(fā)老年癡呆癥疾病的全新突破口，通過確定遺忘分子，來開發(fā)抑制加速遺忘的藥物，以期從記憶層面來改善老年癡呆疾病的新藥。目前老年癡呆（AD）新藥開發(fā)（first-in-class類）獲得CDE審批,已經在宣武,協(xié)和等醫(yī)院開展臨床研究。

國家萬人計劃領軍人才（2020）

科技部中青年創(chuàng)新科技人才（2020）

德國拜耳研究員（2015和2018）

湖北省自然科學二等獎（2016）

OCF雜志特別研究員（Emerging Investigator）（2015）

歐洲雜志Natural Products Against Cancer主編（2012-2014）

Asia Core Program Lectureship（日本，2013）

新加坡國立大學(NUS) Assistant Professorship(2009)

新加坡南洋理工大學(NTU) Nanyang Assistant Professorship(2009)

1.Li, L. Y.; Wang, X.; Gao, R.; Zhang, B.; Liu, Y.; Zhou, J.; Fu, L.; Wang, J*; Inflammation-Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging-Guided Therapy of Rheumatoid Arthritis，Adv. Sci., 2022, 2105188.

2.Peng, Q.; Yan, B..; Li, F.; Lang, M.; Zhang, B.; Guo, D.; Bierer, D.; Wang, J*; Biomimetic Enantioselective Synthesis of β,β-Difluoro-α-amino Acid Derivatives，Commun. Chem., 2021, 4, 148.

3.Li, L.; Zhang, B.; Liu, Y.; Gao, R.; Zhou, J.; Fu, L.; Wang, J*; A Spontaneous Membrane-Adsorption Approach to Enhancing Second Near-Infrared Deep-Imaging-Guided Intracranial Tumor Therapy，ACS Nano, 2021, 15, 4518.

4.Yang, G. M.; Guo, D. H.; Meng, D.; Wang, J*; NHC-catalyzed Atropoenantioselective Synthesis of Axially Chiral Biaryl Amino Alcohols via a Cooperative Strategy，Nature Commun., 2019, 10, 3062.

5.Zhao, C. G；Guo, D. H.; Munkerup, K.; Huang, K. W.； Li， F. Y.; Wang, J*; Enantioselective [3+3] Atroposelective Annulation Catalyzed by N-heterocyclic Carbenes，Nature Commun., 2018, 9, 611.

6.Peng， Q. P.; Guo, D. H.; Bie, J. B.; Wang, J*; Catalytic Enantioselective Aza‐Benzoin Reactions of Aldehydes with 2H‐Azirines, Angew. Chem. Int. Ed., 2018, 57, 3761.

7.Zhang, J. W.; Wang, J*; Atropoenantioselective Redox‐Neutral Amination of Biaryl Compounds through Borrowing Hydrogen and Dynamic Kinetic Resolution, Angew. Chem. Int. Ed., 2018, 57, 465.

8.Wu, Z. J.; Wang, J*; A Tandem Dearomatization/Rearomatization Strategy: Enantioselective N-Heterocyclic Carbene-Catalyzed α-Arylation, Chem. Sci., 2019, 10, 2501.

9.Wu, J. C.; Zhao, C. G.; Wang, J*; Enantioselective Intermolecular Enamide-Aldehyde Cross-Coupling Catalyzed by Chiral N-Heterocyclic Carbenes, J. Am. Chem. Soc., 2016, 138, 4706.

2. Zhao, C. G.; Li, F. Y.; Wang, J*; N-heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones, Angew. Chem. Int. Ed., 2016, 55, 1820.

10.Zhao, C. G.; Li, F. Y.; Wang, J*; N-heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones, Angew. Chem. Int. Ed., 2016, 55, 1820.

11.Wu, J. C.; Xu, W. B.; Yu, Z.-X.*; Wang, J*; Ruthenium-catalyzed Formal Dehydrative [4 + 2] Cycloaddition of Enamides and Alkynes for the Synthesis of Highly Substituted Pyridines: Reaction Development and Mechanistic Study, J. Am. Chem. Soc., 2015, 137, 9489.

12.Wu, Z. J.; Li, F. Y.; Wang, J*; Intermolecular Dynamic Kinetic Resolution Cooperatively Catalyzed by an N-Heterocyclic Carbene and a Lewis Acid, Angew. Chem. Int. Ed., 2015, 54, 1629.

13.Li, F. Y.; Wu, Z. J.; Wang, J*; Oxidative Enantioselective α-Fluorination of Aliphatic Aldehydes Enabled by N-Heterocyclic Carbene Catalysis, Angew. Chem. Int. Ed., 2015, 54, 656.

14.Li, W. J.; Wang, J*; Lewis Base Catalyzed Aerobic Oxidative Intermolecular Azide-Zwitterion Cycloaddition, Angew. Chem. Int. Ed., 2014, 53, 14186.

15.Wang, L.; Huang, J. Y.; Liu, H.; Peng, S. Y.; Jiang, X.-F.*; Wang, J.* Palladium-catalyzed Oxidative Cycloaddition via C–H/N–H Activation: Access to Benzazepines, Angew. Chem. Int. Ed., 2013, 52, 1768.

16.Boitano, A. E.; Wang, J.; Romeo, R.; Bouchez, L. G.; Parker, A. E; Sutton, S. U.; Walker, J. R.; Flaveny, C. A.; Perdew, G. H; Denison, M. S.; Schultz, P. G., Cooke, M. P. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells, Science 2010, 329, 1345-1348.

17.Zhu, S. T.; Wurdak, H.; Wang, J.; Lyssiotis, C. A.; Peters, E. C.; Cho, C. Y.; Wu, X.; Schultz, P. G. A Small Molecule Primes Embryonic Stem Cells for Differentiation, Cell Stem Cell, 2009, 4(5), 416-426.

18.Wang, J.; Xie, H.-X.; Li, H.; Zu, L.-S.; Wang, W. A Highly Stereoselective Hydrogen-Bond-Mediated Michael-Michael Cascade Process through Dynamic Kinetic Resolution, Angew. Chem. Int. Ed., 2008, 47, 4177.

19.Wang, J.; Li, H.; Zu, L.-S.; Wang, W. Organcatalytic Enantioselective Conjugate Additions to Enones, J. Am. Chem. Soc., 2006, 128, 12652.

20.Wang, J.; Li, H.; Xie, H.-X.; Zu, L.-S.; Shen, X.; Wang, W. Organocatalytic Enantioselective Cascade Michael-Aldol Condensation Reactions: Efficient Assembly of Densely Functionalized Chiral Cyclopentenes, Angew. Chem. Int. Ed., 2007, 46, 9050.

21.Wang, J.; Li, H.; Wang, W.; Direct, Highly Enantioselective Pyrrolidine Sulfonamide Catalyzed Michael Addition Reactions of Aldehydes to Nitrostyrenes, Angew. Chem. Int. Ed., 2005, 44, 1369.

---

專利

---