Research Papers(Selected):
1. H. Liu, F. Mei, R. Ye, S. Wang, Y. Ding, X. Han, Y. Zhi, K. Pang, B. Lu (2024) APOE3ch alleviates Aβ and tau pathology and neurodegeneration in the human APPNL-G-F cerebral organoid model of Alzheimer’s disease. Cell Res. 34(6):451-454. doi: 10.1038/s41422-024-00957-w.
2. F. Mei, C. Zhao, S. Li, Z. Xue, Y. Zhao, Y. Xu, R. Ye, H. You, P. Yu, X. Han, G. Carr, D. R. Weinberger, F. Yang, B. Lu (2024) Ngfr+ cholinergic projection from SI/nBM to mPFC selectively regulates temporal order recognition memory. Nature Communication. 15(1):7342. doi: 10.1038/s41467-024-51707-w.
3. F. Yang, H. You, T. Mizuia, (co-first author), K. Kiyosuea, K. Takao, T. Miyakawa, X. Li, T. Bai, K. Xia, L. Zhang, D. Pang, Y. Xu, C. Zhu, M. Kojima, B. Lu (2024) Inhibiting proBDNF to mature BDNF conversion leads to ASD-like phenotypes in vivo. Mol. Psychiatry. doi: 10.1038/s41380-024-02595-5.
4. F. W. Pun, B. H. M Liu, X. Long, J. D. Rothstein, M. E. Cudkowicz, I. V. Ozerov, H. W. Leung, G. H. D. Leung, A. Shneyderman, J. Wang, F. Ren, A. Aliper, X. Guan, B. Lu (co-corresponding author), A. Zhavoronkov, (2022) Identification of therapeutic targets and drug repurposing candidates for amyotrophic lateral sclerosis using PandaOmicsTM – an AI-enabled biological target discovery platform. Frontier in Aging Neuroscie. 14: 914017.
5. X. Qin, Y. Zhao, Y. Xu, T. Zhang, C. Yin. J. Qiao, W. Guo, B Lu (2022) TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice. Nature Communication. 13(1): 914.
6. K. Pang, R. Jiang, W. Zhang, Z. Yang, L. Li, M. Shimozawa, S. Tambaro, J. Mayer, B. Zhang, M. Li, J. Wang, H. Liu, A. Yang, X. Chen, J. Liu, B. Winblad, H. Han, T. Jiang, W. Wang, P. Nilsson, W. Guo, B. Lu (2021) An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments. Cell Research. 32(2): 157–175.
7. J. Liu, Q. Chen, S. Yang, Y. Li, Y. Dou, Y-Q. Deng, J. Bi, Y. Tan, H. Wang, W. Gong, X. Xu, Z. Li, G. Lang, C-F. Qin, B. Lu (co-corresponding author), W. Jiang (2021) hACE2 Fc-neutralization antibody cocktail provides synergistic protection against SARS-CoV-2 and its spike RBD variants. Cell Discovery. 7(1):54.
8. S. Wang, H. Yao, Y. Xu, R. Hao, W. Zhang, H. Liu, Y. Huang, W. Guo, B. Lu (2020). Therapeutic potential of a TrkB agonist antibody for Alzheimer’s disease. Theranostics. 10: 6854-6874.
9. W. Guo, Y. Chen, K. Pang, H. Li, S. Wang, H. Yao1, Y. Xu, H. Liu, V. Lopes-Rodrigues, W. Wu, B. Lu (2019). TrkB agonist antibodies with unique properties superior to BDNF: Utility in treating motoneuron degeneration. Neurobiology of Diseases. 132：104590.
10. F. Han, X. M. Guan, W. Guo, B. Lu (2019) Therapeutic potential of a TrkB agonistic antibody for ischemic brain injury. Neurobiology of Diseases. 127:570-581.
11. J. Guo, Y. Ji, Y. Ding, W. Jiang, Y. Sun, B. Lu (co-corresponding author) and G. Nagappan. (2016) BDNF pro-peptide regulates dendritic spines via caspase-3. Cell Death and Disease. 7(6):e2264
12. P. Pang, G. Nagappan, W. Guo , B. Lu. (2016). Extracellular and intracellular cleavages of proBDNF required at two distinct stages of late-phase LTP. npj Science of Learning. 1, 16003.
13. W. Guo, Y. Ji, S. Wang, Y. Sun, B. Lu (2014) Neuronal activity alters BDNF- TrkB signaling kinetics and downstream functions. J. Cell Sci. 127, 2249-2260.
14. K. Sakata, K. Martinowich ( co-first author), N. H. Woo, R. Schlosser, L. Shen, B. Lu (2013) Activity-dependent BDNF transcription regulates hippocampal late-phase LTP and behavioral perseverance. Proc. Natl. Acad. Sci. USA. 110(37):15103-8.
15. H. –S. Je, F. Yang, Y. Ji, G. Nagappan, B. Hempstead, and B. Lu (2012). Role of proBDNF to mature BDNF conversion in activity-dependent competition at developing neuromuscular synapses. Proc. Natl. Acad. Sci. USA. 109, 15924-15929.
16. J. Y. Kim, C. Liu, F. Zhang, X. Duan, Z. Wen, J. Song, E. Feighery, B. Lu, D. Rujescu, D. S. Clair, K. Christian, J. H. Callicott, D. R. Weinberger, H. Song and G. -l. Ming (2012) Interplay between DISC1 and GABA Signaling Regulates Neurogenesis in Mice and Risk for Schizophrenia. Cell. 5, 1051-1064.
17. K. Zheng, J. J. An, F. Yang, W. Xu, Z. Xu, J. Wu, T. H?kfelt, A. Fisahn, B. Xu, and B. Lu (2011) TrkB Signaling in Parvalbumin-Positive Interneurons Is Critical for gamma-band network synchronization in hippocampus. Proc. Natl. Acad. Sci. USA. 108, 17201-17206.
18. Y. Jiao, Z. Zhang, C. Zhang, X. Wang, K. Sakata, B. Lu , (co-corresponding author), and Q. -Q. Sun (2011) A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo. Proc. Natl. Acad. Sci. USA. 108, 12131-12136.
19. Y. Ji, Y. Lu, F. Yang, W. Shen, T. T. Tang, L. Feng, S. Duan, and B. Lu (2010) Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nature Neuroscience 13, 302-309.
20. B. Fritsch, J. Reis, K. Martinowich, H. M. Schambra, Y. Ji, L. Cohen, and B. Lu (2010) Direct Current Stimulation Promotes BDNF-Dependent Synaptic Plasticity: Potential Implications for Motor Learning. Neuron 66, 198-204.
21. T. T. Tang, F. Yang, B. Chen, Y. Lu, Y. Ji, K. Roche (co-corresponding author), and B. Lu (2009) Dysbindin regulates hippocampal LTP by controlling NMDA receptor surface expression. Proc. Natl. Acad. Sci. USA 106, 21395-400.
22. Y. Ji, F. Yang, F. Papaleo ( co-first author), H. Wang, W. Gao, D. R. Weinberger, and B. Lu (2009) Role of dysbindin in dopamine receptor trafficking and cortical GABA function. Proc. Natl. Acad. Sci. USA 106, 19593–98.
23. S. J, Huffaker, J. Chen, K. Nicodemus, F Sambataro, F. Yang, V. Mattay, B. Lipska, T. M. Hyde, J. Song, D. Rujescu, I. Giegling, K. Mayilyan, M. J. Proust, A. Soghoyan, G. Caforio, J. H. Callicott, A. Bertolino , A. Meyer-Lindenberg , J. Chang, Y. Ji , M. Egan, T. Goldberg, K. E. Kleinman, B. Lu, D. R. Weinberger (2009) A novel, primate-specific brain isoform of KCNH2 affects cortical physiology, cognition, neuronal repolarization and risk of schizophrenia. Nature Medicine 5, 509-518.
24. K. Sakata, N. H. Woo, K. Martinowich, J. S. Greene, R. Schlosser, L. Shen, B. Lu (2009) Critical role f promoter-IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex. Proc. Natl. Acad. Sci. USA 106, 5942–5947.
25. G. Nagappan, E. Zaitsev, V. V. Senatorov, Jr., J. Yang, B. Hempstead, B. Lu (2009) Control of extracellular cleavage of proBDNF by high-frequency neuronal activity. Proc. Natl. Acad. Sci. USA. 106, 1267-1272.
26. J. J. An, K. Gharami, G. –Y. Liao, N. H. Woo, A. G. Lau, F. Vanevski, E. R. Torre, K. R. Jones, Y. Feng, B. Lu, B. Xu (2008) Distinct role of long 3’UTR BDNF mRNA in spine morphology and synaptic plasticity in hippocampal neurons. Cell 134, 175-187.
27. X. Duan, J. H. Chang, S. Ge, R. L. Faulkner, J. Y. Kim, Y. Kitabatake, X. –b. Liu, C-H. Yang, D. Jordan, D. K. Ma, C. Y. Liu, H.-J. Cheng, G. –l. Ming, B. Lu ( co-corresponding author), and H. Song (2007) Disrupted-In-Schizophrenia 1 regulates development of newly generated neurons in the adult brain. Cell. 130; 1146-1158.
28. N. H. Woo, H.K. Teng, C. –J. Siao, C. Chiaruttini, P. T. Pang, T. A. Milner, B. L. Hempstead, and B. Lu (2005) Activation of p75 NTR by proBDNF facilitates hippocampal long-term depression. Nature Neuroscience 8, 1069-1077.
29. Y. Ji, P. T. Pang, L. Feng, and B. Lu (2005) Cyclic AMP controls BDNF-induced TrkB phosphorylation and dendritic spine formation in mature hippocampal neurons. Nature Neuroscience. 8, 164-172.
30. P. T. Pang, H. K. Teng, E. Zaitsev, N. Woo, K. Sakata, S. Zhen, K. K. Teng, W.-H. Yung, B. L. Hempstead, and B. Lu (2004) Cleavage of ProBDNF by tPA/plasmin is essential for long-term hippocampal plasticity. Science. 306, 487-491.
31. M. F. Egan, M. Kojima, J. H. Callicott, T. E. Goldberg, B. S. Kolachana, A. Bertolino, E. Zaistev, B. Gold, D. Goldman, M. Dean, B. Lu, ( co-corresponding author) and D. R. Weinberger (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112, 257-269.
32. C. Wang, F. Yang, X. He, A. Chow, J. Du, J. Russell, and B. Lu (2001) Ca 2+-binding protein frequenin mediates GDNF-induced potentiation of Ca 2+ channels and transmitter release. Neuron 32, 99-112.
33. F. Yang, L. Feng, Z. Fang, S. W. Johnson, J. Du, L. Shen, C. -P. Wu, and B. Lu (2001) GDNF acutely modulates excitability and A-type K + channels in midbrain dopaminergic neurons. Nature Neurosci. 4, 1071-1078.
34. F. Yang, X. He, L. Feng, K. Mizuno, X. Liu, J. Russell, W. Xiong, and B. Lu (2001) PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation. Nature Neurosci. 4, 19-28. With News and Views comments by David Kaplan and Ellis Copper, 4, 5-7.
35. A. Figurov, L. Pozzo-Miller, T. Wang, P. Olafsson, and B. Lu (1996) Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus. Nature 381, 706-709.
36. P. Olafsson, T. Wang, and B. Lu (1995) Molecular cloning and functional characterization of Xenopus Ca 2+- binding protein frequenin. Proc. Natl. Acad. Sci. USA 92, 8001-8005 .
37. T. Wang, Z. Xie, and B. Lu (1995) Nitric oxide mediates activity-dependent synaptic suppression at developing neuromuscular synapses. Nature 374, 262-266.
38. H. G. Kim, T. Wang, P. Olafsson, and B. Lu (1994) Neurotrophin-3 potentiates neuronal activity and inhibits g-aminobutyratergic synaptic transmission in cortical neurons. Proc. Natl. Acad. Sci. USA 91, 12341-12345.
39. B. Lu, W. -m. Fu, P. Greengard and M. -m. Poo (1993) Calcitonin gene-related peptide potentiates synaptic responses at developing neuromuscular junction. Nature 363, 76-79.
40. J. Alder, . B. Lu, F. Valtorta, P. Greengard and M. -m. Poo (1992) Calcium-dependent transmitter secretion reconstituted in Xenopus oocytes: Requirement for synaptophysin. Science 257, 657-661.
41. B. Lu, P. Greengard and M. -m. Poo (1992) Exogenous synapsin I promotes functional maturation of developing neuromuscular synapses. Neuron 8, 521-529.
42. B. Lu, M. Yokoyama, C. F. Dreyfus and I. B. Black (1991) Depolarizing stimuli regulate nerve growth factor gene expression in cultured hippocampal neurons. Proc. Natl. Acad. Sci. USA. 88, 6289-6292.
Invited Reviews and Book Chapters
(Selected)
:
1.
B. Lu, G. Nagappan, X. Guan, P. J. Nathan and P. Wren (2013) BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases.
Nature Review Neuroscience. 14(6):401-16.
2. P. J. Nathan, S. R. Cobb,
B. Lu, E. T. Bullmore, C. H. Davies (2011) Studying synaptic plasticity in the human brain and opportunities for drug discovery.
Curr. Opin. Pharmacology. 11, 540-548.
3.
B. Lu, N. H. Woo (2009) BDNF in synaptic plasticity and memory. In Encyclopedia of Neuroscience, Ed. Larry Squire. Academic Press. Oxford. Vol. 2, pp135-143.
4.
B. Lu, and J. Chang (2009) Role of Neurotrophins in Neurogenesis: Functional Significance in Hippocampus-dependent Synaptic Plasticity and Memory. In “Beyond the Synapse: Cell-Cell Signaling in Synaptic Plasticity” R. D. Fields, (Ed.) Cambridge Univ. Press. pp153-159.
5.
B. Lu, K. H. Wang and A. Nose (2009) Molecular mechanisms underlying neural circuit formation. Curr. Opin. Neurobiology. 19, 162-7.
6. G. Nagappan, N. H. Woo and
B. Lu (2008) Ama“Zinc” link between TrkB transactivation and synaptic plasticity.
Neuron, 57, 477-479.
7. K. Martinowich, H. Manji, and
B. Lu (2007) New insights into BDNF function in depression and anxiety.
Nature Neuroscience. 10, 1089-1093.
8. G. Nagappan, and
B. Lu, (2005) Activity-dependent modulation of BDNF receptor TrkB: mechanism and implications.
Trends in Neurosci. 9, 464-471.
9.
B. Lu, P. T. Pang, and N. H. Woo (2005)The Yin and Yang of neurotrophin action.
Nature Review Neuroscience. 8, 603-614.
10. Guhan N. and
B. Lu, (2004) Homer-PIKE Complex: An novel link between mGluR1 and PI3 Kinase.
Trends in Neurosci. 27, 645-648.
11.
B. Lu, (2003) Pro-region of neurotrophins: Role in synaptic modulation.
Neuron. 39, 735-738.
