師資隊(duì)伍 |
劉清飛, PhD

劉清飛,副教授

清華大學(xué)藥學(xué)院黨委書記,藥學(xué)實(shí)驗(yàn)教學(xué)中心(校級)主任,清華大學(xué)北京市中醫(yī)藥交叉研究所常務(wù)副所長。1993年畢業(yè)于陜西中醫(yī)學(xué)院藥學(xué)系,獲學(xué)士學(xué)位;2000年畢業(yè)于南京中醫(yī)藥大學(xué)中藥學(xué)院,獲碩士學(xué)位;2003年畢業(yè)于廣州中醫(yī)藥大學(xué)中藥學(xué)院,獲博士學(xué)位;2003-2005年于清華大學(xué)化學(xué)系從事博士后研究工作;2005年于清華大學(xué)醫(yī)學(xué)院工作,其中2009年于比利時(shí)魯汶大學(xué)生物系從事博士后研究工作,2011年11月比利時(shí)魯汶大學(xué)醫(yī)學(xué)院訪問學(xué)者;2015年12月起于清華大學(xué)藥學(xué)院(原醫(yī)學(xué)院藥學(xué)系)工作,其中2017年7月于英國牛津大學(xué)EMI項(xiàng)目研修。 承擔(dān)歐盟Horizon2020、科技部國際合作重點(diǎn)項(xiàng)目、國家自然科學(xué)基金、科技部科技攻關(guān)、粵港澳科技合作、中國博士后科研課題(一等)、清華大學(xué)-魯汶大學(xué)合作項(xiàng)目等科研項(xiàng)目。參與首個(gè)網(wǎng)絡(luò)藥理學(xué)國際標(biāo)準(zhǔn)的制訂,出版合著專著4部,參與翻譯著作1部,其中《中醫(yī)藥系統(tǒng)生物學(xué)》(中、英文版)為國內(nèi)外第一部中醫(yī)藥系統(tǒng)生物學(xué)研究專著。


課程教學(xué)

(1)專業(yè)課程:《藥劑學(xué)》(清華大學(xué)精品課、課程思政示范課),《藥劑學(xué)實(shí)驗(yàn)》,《藥學(xué)綜合實(shí)驗(yàn)》,《藥學(xué)社會(huì)實(shí)踐》。
(2)清華大學(xué)通識(shí)課程:《傳統(tǒng)與現(xiàn)代:中醫(yī)藥科學(xué)研究進(jìn)展》。
(3)探究課:《實(shí)驗(yàn)室科研探究》第八十三單元。


研究方向

(1)新型載藥系統(tǒng)的研究開發(fā)。通過緩控釋制劑、納米藥物制劑與環(huán)境響應(yīng)型制劑的開發(fā),提高藥物的生物利用度與遞送效率。
(2)中藥物質(zhì)基礎(chǔ)與作用機(jī)理研究。基于成分分析、組學(xué)研究及藥效評價(jià),結(jié)合網(wǎng)絡(luò)藥理學(xué),探討中藥藥性與炮制機(jī)理、中醫(yī)證候機(jī)制以及中藥復(fù)方物質(zhì)基礎(chǔ)與作用機(jī)理,開發(fā)新型中藥制劑。
(3)藥物代謝動(dòng)力學(xué)研究。基于LC/MS檢測、計(jì)算方法開發(fā),明確藥物制劑或中藥有效成分的ADME特征。


榮譽(yù)和獎(jiǎng)勵(lì)

北京市普通高校本科畢業(yè)設(shè)計(jì)論文優(yōu)秀指導(dǎo)教師(2022);首都大學(xué)生社會(huì)實(shí)踐先進(jìn)工作者(2022);清華大學(xué)先進(jìn)工作者(2021);清華大學(xué)課程思政示范教師(2023);清華大學(xué)優(yōu)秀教學(xué)獎(jiǎng)(2022,2021,2019);清華大學(xué)教學(xué)成果獎(jiǎng)(2021,2016);清華大學(xué)實(shí)驗(yàn)技術(shù)成果獎(jiǎng)(2022,2016,2014);清華大學(xué)劉冰獎(jiǎng)(2019);清華大學(xué)優(yōu)秀黨支部書記(2019);清華大學(xué)學(xué)生社會(huì)實(shí)踐優(yōu)秀指導(dǎo)教師(2022,2018);清華大學(xué)教師身份林楓輔導(dǎo)員獎(jiǎng)(2017);清華大學(xué)優(yōu)秀黨建與思想政治工作者(2017);清華大學(xué)就業(yè)工作先進(jìn)個(gè)人(2016);清華大學(xué)“挑戰(zhàn)杯”優(yōu)秀指導(dǎo)教師(2016);清華大學(xué)宣傳工作先進(jìn)個(gè)人(2014)。

代表論著

專著

1. Guoan Luo, Yiming Wang, Qionglin Liang, Qingfei Liu. System biology for TCM, John Wiley Press, 2012

2. 羅國安,王義明,梁瓊麟, 劉清飛。中醫(yī)藥系統(tǒng)生物學(xué)。科學(xué)出版社,2011

3. 藥物新劑型。編委,化學(xué)工業(yè)出版社,2003

論文

1. Jing Jiang, Fuguo Han, Kaixuan Cai, Qiushuo Shen, Cuiping Yang, Anli Gao, Juan Yu, Xuemei Fan, Yanli Hao, Zhao Wang, Weiping Liu*, Yun Shi*, Qingfei Liu*. Synthesis and biological evaluation of cholic acid-conjugated oxaliplatin as a new prodrug for liver cancer. Journal of Inorganic Biochemistry, 2023, 243, 112200.

2. Yifei Liu, Xuemei Fan, Huanhuan Pang, Saiya Liu, Bohong Wang, Chunmei Wang, Qingya Yan, Wenping Song, Zeping Hu*, Qingfei Liu*, Yun Shi*. Metabolomics reveals a panel of biomarkers for early human embryonic development arrest. Journal of Proteome Research, 2023, 22, 1280-1286.

3. Fei Yan, Qi Zhao, Huanpeng Gao, Xiaomei Wang, Ke Xu, Yishu Wang, Fuguo Han, Qingfei Liu*, Yun Shi*. Exploring the mechanism of (-)-Epicatechin on premature ovarian insufficiency based on network pharmacology and experimental evaluation. Bioscience Report, 2021, 41, BSR20203955.

4. Xianzhi Su, Xiaomei Wang, Yifei Liu, Wenjuan Kong, Fei Yan, Fuguo Han, Qingfei Liu*, Yun Shi*. Effect of Jiajian Guishen Formula on the senescence-associated heterochromatic foci in mouse ovaria after induction of premature ovarian aging by the endocrine-disrupting agent 4-vinylcyclohexene diepoxide. Journal of Ethnopharmacology, 2021, 269, 113720.

5 Yingxue Li, Fanzhuo Meng, Zhijian Chen, Fuguo Han, Donglin He, Anli Gao, Jing Jiang, Weiping Liu*, Qingfei Liu*. Pharmacokinetics and tissue distribution of a novel anticancer platinum compound LLC-1903 to rats. Xenobiotica, 2020, 50(8), 980-987.

6. Huang Qing; Li Liyuan; Chen Huiling; Liu Qingfei*; Wang Zhao*. GPP (composition of Ganoderma lucidum poly-saccharides and Polyporus umbellatus poly-saccharides) enhances innate immune function in Mice. Nutrients, 2019, 11, 1480.

7. Chen Huiling; Huang Qing; Zhang Shunjia; Hu Kaiqiang; Xiong Wenxiang; Xiao Lingyun; Cong Renhuai; Liu Qingfei*; Wang Zhao*. The Chinese herbal formula PAPZ ameliorates behavioral abnormalities in depressive mice. Nutrients, 2019, 11(4), 859.

8. Huan-Huan Qiao, Fang Wang, Rong-Gang Xu, Jin Sun, Ruibao Zhu, Decai Mao, Xingjie Ren, Xia Wang, Yu Jia, Ping Peng, Da Shen, Lu-Ping Liu, Zhijie Chang, Guirong Wang, Shao Li, Jun-Yuan Ji, Qingfei Liu, Jian-Quan Ni*. An efficient and multiple target transgenic RNAi technique with low toxicity in Drosophila. Nature Communications, 2018, 9, 4160.

9. Yu Jia, Rong-Gang Xua, Xingjie Ren, Ben Ewen-Campenc, Rajendhran Rajakumar, Jonathan Zirin, Donghui Yang-Zhou, Ruibao Zhu, Fang Wang, Decai Mao, Ping Peng, Huan-Huan Qiao, Xia Wang, Lu-Ping Liu, Bowen Xu, Jun-Yuan Ji, Qingfei Liu, Jin Sun, Norbert Perrimon, and Jian-Quan Ni*. Next-generation CRISPR/Cas9 transcriptional activation in Drosophila using flySAM. PNAS, 2018, 115(18), 4719-4724.

10. Ren Xingjie; Holsteens Kristof; Li Haiyi; Sun Jin; Zhang Yifan; Liu Lu-Ping; Liu Qingfei*; Ni Jianquan*. Genome editing in Drosophila melanogaster: from basic genome engineering to the multipurpose CRISPR-Cas9 system. Science China-life Sciences, 2017, 60(5), 476-489.

11. Donglin He, Shuhui Yin, Fuguo Han, Jingjie Zhu, Yun Shi, Zhiyuan Tong, Qingfei Liu*. Pharmacokinetics and tissue distribution of two novel isomerism anticancer platinum compounds. Drug Development and Industrial Pharmacy, 2016, 42(11), 1792-1799.

12. Zhengguang Li, Rui Zhang, Xiuping Wang, Xiaofei Hu, Yuguo Chen*, Qingfei Liu*. Simultaneous determination of seven ginsenosides in rat plasma by high performance liquid chromatography coupled to time-of-flight mass spectrometry: Application to pharmacokinetics of Shenfu injection. Biomedical Chromatography, 2015, 29(2), 167-175.

13. Qingfei Liu, Yun Shi, Tuo Guo, Yong Wang, Wenjuan Cong, Jingjie Zhu. Metabolite discovery of helicidum in rat urine with XCMS based on the data of ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. Journal of Chromatography B, 2012, 907, 146-153.

14Qingfei Liu, Walter Luyten, Klaartje Pellens, Yiming Wang, Wei Wang, Karin Thevissen, Qionglin Liang, Bruno P.A. Cammue, Liliane Schoofs, Guoan Luo. Screening for antifungal plants from Chinese traditional and folk medicines, Journal of Ethnopharmacology, 2012, 143(3), 772-778.

15Jun Shi, Qingfei Liu*, Yiming Wang, Guoan Luo*. Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats. Pharmacology, Biochemistry and Behavior, 2010, 96, 449-453.

16. Wenjuan Cong, Qingfei Liu*, Xi Chen, Rong Gao, Juan Lu, Yiming Wang, Guoan Luo*. Characterization and pharmacokinetics of a novel pirarubicin liposome powder. Drug Development and Industrial Pharmacy, 2010, 143, 154-160.

17. Wenjuan Cong, Qingfei Liu*, Yiming Wang, Guoan Luo*. Investigation on the interactions between pirarubicin and phospholipids. Biophysical Chemistry, 2009, 143, 154-160.

18. Qingfei Liu, Yun Shi, Yong Wang, Juan Lu, Wenjuan Cong, Guoan Luo, Yiming Wang. Metabolism profile of scutellarin in rat urine following oral administration by ultra performance liquid chromatography coupled to time-of-flight mass spectrometry. Talanta, 2009, 80, 84-91.

19Qingfei LiuYun Shi, Yuzhen Zhang, Zhongmin Song, Qiang Su, Yu Zhang, Guoan Luo. A simple and rapid method for determination of pennogenin diglycoside in rat plasma by high performance liquid chromatography mass spectrometry: application to the pharmacokinetics of Gongxuening Capsules. Journal of Chromatographic Science, 2009, 47(8), 728-732.

20. Qingfei Liu, Xue Li, Qiang SuGuoan Luo, Yiming Wang, Weiping Liu. Investigation on pharmacokinetics, tissue distribution and excretion of a novel anticancer platinum compound by inductively coupled plasma mass spectrometry after intravenous administration to rats. Archives of Pharmacal Research, 2009, 32 (11), 1621-1628.

21. Su Qiang, Liu Qingfei*, Wang Yong, Bi Kaishun, Luo Guoan*. Rapid and sensitive assay on the main components in Shuang-Huang-Lian preparations by UPLC-TOF-MS. Chemical Research in Chinese Universities, 2009, 25(1), 122-124.

22. Qingfei Liu, Xiangdong Liu, Guoan Luo, Weiwei Tian, Yiming Wang. Determination of helicidum and its metabolites in dog plasma by LC/UV/MS/MS and its application to pharmacokinetic studies. Journal of Chromatography B, 2006, 832, 185-190.


Tel: +86-10-62797450

Email: liuqf@tsinghua.edu.cn


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