師資隊伍 |
郝艷麗,PhD

郝艷麗,高級工程師

?清華大學藥學實驗教學中心(校級)副主任、藥學院學生工作組組長。1999年畢業(yè)于鄭州大學藥學院,獲得理學學士學位;2005年畢業(yè)于沈陽藥科大學,獲得藥劑學專業(yè)博士學位;2005-2007年在清華大學生物學博士后流動站從事博士后研究;2015.12-2016.1于德國弗賴堡大學從事訪問學者(DAAD-CSC);2007年至今在清華大學醫(yī)學院、藥學院工作,主要從事藥學相關(guān)教學科研與學生管理工作。擔任教育部全國本科畢業(yè)論文(設(shè)計)抽檢評審專家?guī)鞂<摇⒅袊t(yī)藥生物技術(shù)協(xié)會-藥物分析技術(shù)分會第二屆委員會委員、第14屆九三學社北京市委科技專委會委員等。


課程教學:

《藥事管理學》、《藥物化學實驗》、《藥理毒理實驗》、《綜合論文訓練》、《藥學實踐C》、《藥學綜合實驗》

研究方向:

研究方向為新型藥物遞送系統(tǒng)。研究工作主要聚焦在新型納米載體和聚合物載體作為藥物遞送系統(tǒng)的設(shè)計和應用。曾主持承擔和參加多項國家級課題,包括國家自然科學基金面上項目、國家重大新藥創(chuàng)制、863課題等,參與出版專著1部、教材2部,發(fā)表論文30余篇,授權(quán)專利多項。

發(fā)表文章:

1. Jun Li, Lei Chen, Nan Liu, Shengnan Li, Yanli Hao*, Xiaoning Zhang*; EGFcoated nanodendriplexes for tumor targeted nucleic acid delivery in vivo., Drug Delivery, 2016, 23(5): 1718-1725

2. Jun Li, Shengnan Li, Songyun Xia, Jinfeng Feng, Yanli Hao*, Lei Chen*, Xiaoning Zhang*. 2015. Enhanced transfection efficiency and targeted delivery of self-assembling h-R3-dendriplexes in EGFR-overexpressing tumor cells. Oncotarget, Early Online, 6: 26177-91.

3.Yanli Hao*, Lan Wang, Jun Li, Nan Liu, Jinfeng Feng, Mojiao Zhao, Xiaoning Zhang*. 2015. Enhancement of solubility, transport across MDCK monolayer and oral absorption of pranlukast by preparing pranlukast-phospholipid complex. J. Biomedical Nanotechnology, 11(3): 469-477(9)

4.Anil Kumar, Fei Chen, Anbu Mozhi,Xu Zhang, Yuanyuan Zhao, Xiangdong Xue, Yanli Hao, Xiaoning Zhang, and Xing-Jie Liang*. 2013. Innovative pharmaceutical development based on unique properties of nanoscale delivery formulation. Nanoscale, 5:8307-8325.

5.Zhe Yin, Nan Liu, Mingshu Ma, Lan Wang, Xing-Jie Liang, Yanli Hao*, Xiaoning Zhang*. 2012. A novel EGFR-targeted gene delivery system based on complexes self-assembled by EGF, DNA and activated PAMAM dendrimers, In J Nanomedicine 7, pp 4625-4635.

6.Nan Liu, Yanli Hao*, Zhe Yin, Mingshu Ma, Lan Wang, Xiaoning Zhang*. 2012. Self-Assembled Human Serum Albumin-Coated Complexes for Gene Delivery with Improved Transfection. Die Pharmazie, 67(2): 174-181.

Mingshu Ma, Yanli Hao*, Nan Liu, Zhe Yin, Lan Wang, Xing-Jie Liang, Xiaoning Zhang*. 2012. A novel lipid-based nano-micelle of docetaxel: evaluated antitumor efficiency and biodistribution with optical imaging in vivo. In J Nanomedicine,7, pp 3389-3398.

7.Lan Wang, Yanli Hao*, Nan Liu, Zhe Yin, Mingshu Ma, Xiaoning Zhang*. 2012. Enhance the dissolution rate and oral bioavailability of pranlukast by preparing nanosuspensions with high-pressure homogenizing method. Drug Development and Industrial Pharmacy, 38(11):1381-1389.

8.Chunlei Li, Jingxia Cui, Yingui Li, Caixia Wang, Yanhui Li, Lan Zhang, Li Zhang, Wenmin Guo, Jinxu Wang, Hongwu Zhang, Yanli Hao, Yongli Wang. 2008. Copper ion-mediated liposomal encapsulation of mitoxantrone:The role of anions in drug loading, retention and release. Eur. J Pharm. Sci, 34(4-5):333-344.

Jingxia Cui, Chunlei Li, Yanhui Li, Caixia Wang, Li Zhang, Lan Zhang, Yanli Hao,Yongli Wang. 2007. Direct comparison of two pegylated liposomal doxorubicin formulations: Is AUC predictive for toxicity and efficacy? J Controlled Release, 118(2):204-215.

9.Aijun Hao, Yingjie Deng, Tiefu Li, Xubin Suo, Yanhai Cao, Yanli Hao, Yong Zhang. 2006. Degradation kinetics of fluorouracil-acid-dextran conjugate in aqueous solution. Drug Development and Industrial Pharmacy, 32(6):757-763.

10.Yanli Hao, Yingjie Deng, Yan Chen, Kezhan Wang, Aijun Hao and Yong Zhang. 2005. In vitro cytotoxicity, in vivo biodistribution and anti-tumor effect of PEGlyated liposome containing topotecan. J Pharmacy and Pharmacology, 57: 1279-1287.

11.Yanli Hao, Yingjie Deng, Yan Chen, Xiumin Wang, Haijun Zhong and Xubin Suo. 2005. In-Vitro and In-Vivo Studies of Different Liposomes Containing Topotecan. Archives of Pharmacal Research, 28(5): 626-635.

12.Yanli Hao, Yingjie Deng, Yan Chen and Youcai Hu. Synthesis 3-4-2-hydroxyl-(1-methyl ethylamine) propyl oxygen}phenyl}propionic acid cetylester as Potential Ligand for Liposome Targeting to Ischemic Myocardium. Chinese Chemical Letters, 16(8):1004-1006.

13.Yan Chen, Yingjie Deng, Yanli Hao. 2005. Surface modification of liposomes for selective cardiomyocytes targeting in vitro. Die Pharmazie, 60(3): 238-240.

14.Yan Chen, Yingjie Deng, Yanli Hao, Aijun Hao, Haijun Zhong and Xiumin Wang. 2005. Uptake of liposomes by cultured cardiomyocytes. Die Pharmazie, 60(11):844-848.

榮譽與獎勵:

清華大學優(yōu)秀班主任一等獎(2025、2018)

清華大學教學成果二等獎(2025、2016)

清華大學優(yōu)秀黨建與思政工作者(2025)

清華大學先進工作者(2024)

清華大學愛崗敬業(yè)獎(2024)

清華大學教職工粉筆板書比賽二等獎(2025、2024)

清華大學優(yōu)秀招生教師(2023)

清華大學實驗技術(shù)成果獎二等獎(2022)

清華大學優(yōu)秀實驗技術(shù)人員一等獎(2019)

清華大學實驗室建設(shè)與管理獎二等獎(2019、2018)

清華大學第六屆青年教師教學大賽(理工科組)二等獎(2014)

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