我院劉剛教授及其合作者近期在Journal of Medicinal Chemistry在線連續(xù)發(fā)表了兩篇研究性論文。第一篇是將有機(jī)化學(xué)方法學(xué)Late-Stage Functionalization應(yīng)用于藥物化學(xué)的研究中，通過后期的化學(xué)修飾發(fā)現(xiàn)了一類新型P-糖蛋白抑制劑。后一篇內(nèi)容是通過限定小分子的構(gòu)象發(fā)現(xiàn)了新一類HBV殼組裝抑制劑，其前藥可以通過口服在小鼠體內(nèi)有效地抑制HBV復(fù)制。


 
題目1：Discovery of Potent Inhibitors against P?Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2?(4-(Pyridin-2-yl)phenoxy)pyridine Analogue
作者： Yao Ma^# Dawei Yin^# Jingjia Ye^# Xiduan Wei, Yameng Pei, Xueyuan Li, Guangxu Si, Xuan-Yu Chen, Zhe-Sheng Chen, Yi Dong, Feng Zou, Wei Shi, Qianqian Qiu, Hai Qian,* and Gang Liu*（https://dx.doi.org/10.1021/acs.jmedchem.0c00337）


 
題目2：Discovery of (1H-Pyrazolo[3,4-c]pyridin-5-yl)sulfonamide Analogs as Hepatitis B Virus Capsid Assembly Modulators by Conformation Constraint

作者：Chunting Wang^#, Yameng Pei^#, Lin Wang, Shuo Li, Chao Jiang, Xu Tan, Yi Dong, Ye Xiang^*, Yao Ma^*, Gang Liu^* (https://doi.org/10.1021/acs.jmedchem.0c00292)