講座主題：Neural circuits basis of temporal lobe epilepsy
時(shí)間：9月13日10:00-12:00
地點(diǎn)：醫(yī)學(xué)科學(xué)樓B323
主持：陳立功 研究員
個(gè)人簡(jiǎn)介：
陳忠，浙江大學(xué)，教授，博士生導(dǎo)師，浙江大學(xué)醫(yī)藥學(xué)部副主任，教育部長(zhǎng)江學(xué)者特聘教授，國(guó)家杰出青年科學(xué)基金獲得者，國(guó)家政府特殊津貼獲得者，浙江大學(xué)求是特聘教授，國(guó)家自然科學(xué)基金委創(chuàng)新研究群體和教育部創(chuàng)新團(tuán)隊(duì)的核心成員， 浙江大學(xué)癲癇中心主任。
陳忠博士1992年畢業(yè)于上海醫(yī)科大學(xué)藥學(xué)本科，1999年在日本岡山大學(xué)獲得博士學(xué)位。現(xiàn)為中國(guó)藥理學(xué)學(xué)會(huì)常務(wù)理事，中國(guó)藥理學(xué)會(huì)神經(jīng)精神藥理學(xué)專業(yè)委員會(huì)副主任委員，浙江省藥理學(xué)會(huì)理事長(zhǎng)。《Neurosci Bull》和《浙江大學(xué)學(xué)報(bào)》（醫(yī)學(xué)版）副主編，《Exp Neurol》《CNS Neurosci Ther》《Sci Rep》《Acta Pharmacol Sin》以及《藥學(xué)學(xué)報(bào)》《中國(guó)藥理學(xué)通報(bào)》編委。
陳忠教授課題組的主要研究方向?yàn)槟X缺血和癲癇的發(fā)病機(jī)制及藥物治療靶點(diǎn)的研究， 在Neuron，Nature Commun，Nature Neurosci，Angew Chem Int Edit，Autophagy等期刊發(fā)表SCI學(xué)術(shù)論文180余篇, 獲省科技進(jìn)步獎(jiǎng)一等獎(jiǎng)，省自然科學(xué)獎(jiǎng)一等獎(jiǎng)和教育部自然科學(xué)一等獎(jiǎng)各一項(xiàng)。
Abstract：
Temporal lobe epilepsy (TLE) is a common type of epilepsy and not well controlled by current treatments, but the underlying cellular/circuit mechanisms remain unclear. The early series of our studies have proved the success of low-frequency stimulation treatment for epilepsy, which was mainly depending on the stimulation target, the stimulation frequency and stimulation time (the therapeutic-window phenomenon). Now, by using optogenetics, multiple-channel EEG analysis, imaging, electrophysiological and molecular techniques, we are continued to investigate the circuit mechanism of therapeutic deep brain stimulation, and found that entorhinal principal neurons mediate antiepileptic “glutamatergic-GABAergic” neuronal circuit for brain stimulation treatments of epilepsy. Meanwhile, we are currently focusing on the interplay of inhibitory and excitatory network in subicular microcircuits especially that related to the generation of generalized seizures (GS) in TLE, and we found that depolarized GABAergic signaling in subicular microcircuit mediates GS in TLE. This may be of therapeutic interest in understanding the pathological neuronal circuitry and further the development of novel therapeutic approaches.
