實(shí)現(xiàn)了復(fù)雜調(diào)控網(wǎng)絡(luò)的自動(dòng)化設(shè)計(jì)，編輯細(xì)胞進(jìn)行邏輯運(yùn)算，實(shí)現(xiàn)了細(xì)菌、酵母、植物、哺乳動(dòng)物細(xì)胞調(diào)控網(wǎng)絡(luò)的可預(yù)測設(shè)計(jì)。
國家高層次人才計(jì)劃青年項(xiàng)目
生命科學(xué)新力量年度人物
國家優(yōu)秀自費(fèi)留學(xué)生獎(jiǎng)
賓夕法尼亞州立大學(xué)優(yōu)秀博士論文獎(jiǎng)
代表性論文
1. Ziyuan Ma#, Wenjie Li#, Yunhao Shen#, Yunxin Xu#, Gengjiang Liu, Jiamin Chang, Zeju Li, Hong Qin, Boxue Tian, Haipeng Gong, DR. Liu, BW. Thuronyi, CA. Voigt, and Shuyi Zhang*. (2025) EvoAI enables extreme compression and reconstruction of the protein sequence space. Nature Methods, 22,102–112, DOI: 10.1038/s41592-024-02504-2
2. Ci Kong, Yin Yang, Tiancong Qi, and Shuyi Zhang*. (2025) Predictive genetic circuit design for phenotype reprogramming in plants. Nature Communications, 16:715(2025), DOI: 10.1038/s41467-025-56042-2
3. Yichi Zhang and Shuyi Zhang*. (2024) CRISPR perfect adaptation for robust control of cellular immune and apoptotic responses. Nucleic Acids Research, 2024, 52, 10005–10016, DOI: 10.1093/nar/gkae665
4. Shuyi Zhang and Christopher A. Voigt. (2018) Engineered dCas9 with reduced toxicity in bacteria: implications for genetic circuit design. Nucleic Acids Research, gky884, DOI: 10.1093/nar/gky884
5. Shuyi Zhang and Donald A. Bryant. (2015) Biochemical validation of the the glyoxylate cycle in the cyanobacterium Chlorogloeopsis fritschii PCC 9212, Journal of Biological Chemistry 290 (22), 14019-14030, DOI: 10.1074/jbc.M115.648170
6. Fei Gan, Shuyi Zhang, Nathan C. Rockwell, Shelley S. Martin, Clark J. Lagarias and Donald A. Bryant. (2014) Extensive remodeling of a cyanobacterial photosynthetic apparatus in Far-Red light. Science, 345, 1312-1317, DOI: 10.1126/science.1256963
7. Shuyi Zhang and Donald A. Bryant. (2011). The tricarboxylic acid cycle in cyanobacteria. Science, 334, 1551-1553, DOI: 10.1126/science.1210858
- This work was featured as cover story in Chapter 3 of the classic microbiology textbook Brock Biology of Microorganisms (14th Edition)
