4、解析第一個(gè)重金屬轉(zhuǎn)運(yùn)P型ATP酶（銅泵）的高分辨率晶體結(jié)構(gòu)，揭示銅離子跨膜轉(zhuǎn)運(yùn)的分子機(jī)理。(
2013年-2017年: 安進(jìn)中國(guó)博士后獎(jiǎng)學(xué)金。
2012年-2013年: 清華北大生命科學(xué)聯(lián)合中心博士后基金。
代表性論文
1. Xiuqing Lv#, Kaixuan Gao#, Jia Nie#, Xin Zhang, Shuhao Zhang, Yinhang Ren, Xiaoou Sun, Qi Li, Jingrui Huang, Lijuan Liu, Xiaowen Zhang, Weishe Zhang*, Xiangyu Liu*. Structures of human prostaglandin F2α receptor reveal the mechanism of ligand and G protein selectivity. Nature Communications. (2023) 14 (1):8136. doi: 10.1038/s41467-023-43922-8.
2. Xinyu Xu, Jeremy Shonberg, Jonas Kaindl, Mary J. Clark, Anne St??el, Luis Maul, Daniel Mayer, Harald Hübner, Kunio Hirata, A. J. Venkatakrishnan, Ron O. Dror, Brian K. Kobilka*, Roger K. Sunahara*, Xiangyu Liu*, Peter Gmeiner*. Constrained catecholamines gain β2AR selectivity through allosteric effects on pocket dynamics. Nature Communications. (2023) 14, 2138. https://doi.org/10.1038/s41467-023-37808-y
3. Xinyu Xu#, Jonas Kaindl#, Mary J. Clark#, Harald Hübner, Kunio Hirata, Roger K. Sunahara*, Peter Gmeiner*, Brian K. Kobilka, Xiangyu Liu*. (2021) Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR. Cell Research. 31, 569-579.
4. Xiangyu Liu#, Jonas Kaindl#, Magdalena Korczynska, Anne Sto??el, Daniela Dengler, Markus Stanek, Harald Hu?bner, Jake Mahoney, Mary J. Clark, Rachel Ann Matt, Xinyu Xu, Kunio Hirata, Brian K. Shoichet, Roger K. Sunahara*, Brian K. Kobilka*, Peter Gmeiner*. (2020) Discovery of an allosteric modulator binding to a conformational hub in the β2 adrenergic receptor. Nature Chemical Biology. 16, 749-755.
5. Xiangyu Liu#, Ali Masoudi#, Alem W. Kahsai#, Li-Yin Huang, Biswaranjan Pani, Dean P. Staus, Paul J. Shim, Kunio Hirata, Rishabh K. Simhal, Allison M. Schwalb, Paula K. Rambarat, Seungkirl Ahn, Robert J. Lefkowitz*, Brian Kobilka*. (2019) Mechanism of β2AR regulation by an intracellular positive allosteric modulator.Science, 364 (6447):1283-1287.
6. Xiangyu Liu#*,Xinyu Xu#, Daniel Hilger#, Philipp Aschauer, Johanna K.S. Tiemann, Yang Du, Hongtao Liu, Kunio Hirata, Xiaoou Sun, Ramon Guixà-González, Jesper M. Mathiesen, Peter W. Hildebrand, Brian Kobilka*.(2019) Structural insights into the process of GPCR-G protein complex formation.Cell,177(5):1243-1251.
7. Hongtao Liu#, Josefa Hofmann#, Inbar Fish#, Benjamin Schaake, Katrin Eitel, Amelie Bartuschat, Jonas Kaindl, Hannelore Rampp, Ashutosh Banerjee, Harald Hübner, Mary J. Clark, Sandra G. Vincent , John T. Fisher, Markus R. Heinrich, Kunio Hirata, Xiangyu Liu*, Roger K. Sunahara, Brian K. Shoichet*, Brian K. Kobilka*, Peter Gmeiner*. (2018)Structure-guided development of selective muscarinic M3 acetylcholine receptor antagonists.PNAS.,115(47):12046-12050.
8. Xiangyu Liu#,Seungkirl Ahn#, Alem W. Kahsai, Kai-Cheng Meng, Naomi R. Latorraca, Biswaranjan Pani, A. J. Venkatakrishnan, Ali Masoudi, William I. Weis, Ron O. Dror, Xin Chen, Robert J. Lefkowitz*, Brian K. Kobilka*. (2017) Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure. Nature, 548:480-484.
9. Yi-He Huang#, Xiang-Yu Liu#, Xiao-Xia Du, Zheng-Fan Jiang, Xiao-Dong Su. (2012) The Structural Basis for the Sensing and Binding of Cyclic di-GMP by STING. Nature Structural & Molecular Biology,19: 728–730.
10. Pontus Gourdon#, Xiang-Yu Liu#, Tina Skj?rringe, J. Preben Morth, Lisbeth Birk M?ller*, Bj?rn Panyella Pedersen, Poul Nissen*. (2011)Crystal structure of a copper-transporting PIB-type ATPase. Nature, 475: 59-64.
