科學(xué)研究 |
白凈衛(wèi), PhD

白凈衛(wèi)

研究員,博士生導(dǎo)師

白凈衛(wèi)博士本科就讀北京大學(xué)化學(xué)系,2011年6月畢業(yè)于美國(guó)加州大學(xué)洛杉磯分校獲材料學(xué)博士學(xué)位。 2011.6-2013.6,在IBM 沃森實(shí)驗(yàn)室從事博士后研究,后受聘于美國(guó)基因測(cè)序技術(shù)公司Illumina Inc. 從事研發(fā)工作。2016加入清華大學(xué)藥學(xué)院任特聘研究員,博士生導(dǎo)師。攻讀博士期間結(jié)合前沿半導(dǎo)體工藝完成了石墨烯納米篩結(jié)構(gòu)和超高頻石墨烯射頻晶體管等原創(chuàng)性科研成果,為石墨烯電子器件領(lǐng)域進(jìn)展做出了突出貢獻(xiàn)。博后期間在IBM前沿半導(dǎo)體制成技術(shù)的基礎(chǔ)上拓展納米制備技術(shù)在單分子生物傳感器方面的應(yīng)用,領(lǐng)導(dǎo)了基于“Top down”技術(shù)路線制備固態(tài)納米孔的研究工作。之后加入了基因測(cè)序技術(shù)領(lǐng)域處于世界領(lǐng)先地位的Illumina Inc.,負(fù)責(zé)研發(fā)基于納米孔構(gòu)造和納米線晶體管原理的新一代基因測(cè)序技術(shù)。已獲得授權(quán)十余項(xiàng)項(xiàng)。在Nature、Nature Nanotechnology,Nano Letters, PNAS等期刊上發(fā)表論文三十余篇。回到清華大學(xué)藥學(xué)院至今作為課題負(fù)責(zé)人已獲得三項(xiàng)科技部重點(diǎn)項(xiàng)目資助,領(lǐng)導(dǎo)基于納米孔的新一代基因測(cè)序技術(shù)的研發(fā)。


研究方向:

新一代DNA測(cè)序技術(shù)是基于單分子連續(xù)測(cè)序的策略,針對(duì)于核酸分子鏈上的堿基序列進(jìn)行逐個(gè)快速識(shí)別和測(cè)定。而基于納米孔技術(shù)的第四代測(cè)序技術(shù)可直接對(duì)DNA、RNA分子進(jìn)行直接測(cè)序,測(cè)序片段可到數(shù)萬(wàn)以上堿基、儀器尺寸小、測(cè)序速度快、文庫(kù)制備簡(jiǎn)單等優(yōu)勢(shì),在優(yōu)化現(xiàn)有測(cè)序結(jié)果和拓展測(cè)序技術(shù)應(yīng)用領(lǐng)域方面形成“互補(bǔ)”,在病原體微生物監(jiān)測(cè)、基因組結(jié)構(gòu)變異、表觀遺傳修飾、蛋白測(cè)序等方面具有十分重要的應(yīng)用前景。
本課題組主要研究基于納米孔測(cè)序平臺(tái)的底層技術(shù)開發(fā),以及單分子長(zhǎng)度長(zhǎng)測(cè)序技術(shù)的臨床應(yīng)用研究:

1) 納米孔測(cè)序核心技術(shù):主要研究核心納米孔蛋白的進(jìn)化和單分子控速策略。通過(guò)復(fù)合的生物大分子動(dòng)力蛋白,研究核酸、多肽、多糖等線性生物分子在納米孔中的移動(dòng)和相互作用,開發(fā)新型納米孔測(cè)序方法和蛋白互作檢測(cè)技術(shù)。

2) 高通量長(zhǎng)度長(zhǎng)測(cè)序技術(shù)的臨床應(yīng)用:主要研究適應(yīng)于納米孔長(zhǎng)度長(zhǎng)測(cè)序的建庫(kù)方法,應(yīng)用于單細(xì)胞基因組長(zhǎng)度長(zhǎng)測(cè)序、快速靶向建庫(kù)、cfDNA的高通量測(cè)序建庫(kù)、快速去宿主核酸的宏基因組測(cè)序技術(shù)。

3) Point-of-Care核酸檢測(cè)技術(shù):開發(fā)高靈敏度快速核酸等溫?cái)U(kuò)增方法和肉眼可見(jiàn)的顯色技術(shù),實(shí)現(xiàn)不依賴復(fù)雜儀器的快速現(xiàn)場(chǎng)高靈敏度病原體快檢。
 

榮譽(yù)和獎(jiǎng)勵(lì):

IBM First Plateau Invention Achievement Award, IBM T J Watson Research, 2013年
Harry M. Showman Prize, University of California, Los Angeles 2011年
Graduate Student Silver Award, Material Research Society (MRS) Fall Meeting 2010年

 代表論文:

1.     B. Wang, Y. Sun, H. Ding, X. Zhao, L. Zhang, J.W.Bai*, K. Liu*, “Bioelectronics-Related 2D Materials Beyond Graphene: Fundamentals, Properties, and Applications”,Advanced Functional Materials (2020), 2003732.
2.     R.Tian*, Y. Li, J.W.Bai*, “Hierarchical assembled nanomaterial paper based analytical devices for simultaneously electrochemical detection of microRNAs”, Analytica Chimica Acta (2019), 1058, 89.
3.     R. Tian, W. Ning, M. Chen, C. Zhang, Q. Li*, J.W.Bai*, “High performance electrochemical biosensor based on 3D nitrogen-doped reduced graphene oxide electrode and tetrahedra DNA nanostructure”, Talanta (2019), 194, 273.
4.     J. W.  Bai?, D. Wang?, S.W. Nam, H. Peng, R. Bruce, L. Gignac, M. Brink, E. Kratschmer, S. Rossnagel, P. Waggoner, K. Reuter, C. Wang, Y. Astier, V. Balagurusamy, B. Luan, Y. Kwark , E. Joseph, M. Guillorn, S. Polonsky, A. Royyuru, S. Papa Rao, G. Stolovitzky, “Fabrication of sub-20nm nanopore arrays in membranes with embedded metal electrodes at wafer scales”, Nanoscale (2014), 6, 8900.
5.     R. Cheng?, J. W.  Bai? (Co-author with Equal contribution), L. Liao, H. Zhou, Y. Chen, L. Liu, Y.-C. Lin, S. Jiang, Y. Huang, X. F. Duan, “High-frequency self-aligned graphene transistors with transferred gate stacks”, Proceedings of the National Academy of Sciences of The United States of America (2012), 109, 11588.  
6.     J. W.  Bai, L. Liao, H. Zhou, R. Chen, L. Liu, Y. Huang, X. F. Duan, “Top-gated chemical vapor deposition grown graphene transistors with current saturation”, Nano Letters (2011) 11, 2555. 
7.     J. W.  Bai, Y. Huang, “Fabrication and electrical properties of graphene nanoribbons”, Materials Science and Engineering: R (2010) 70, 341. Invited Review 
8.     J. W.  Bai?, R. Cheng?, F. X. Xiu, L. Liao, M. S. Wang, A. Shailos, K. L. Wang, Y. Huang, X. F. Duan, “Very large magnetoresistance in graphene nanoribbons”, Nature Nanotechnology (2010) 5, 655. 
9.     J. W.  Bai, X. Zhong, S. Jiang, Y. Huang, X. F. Duan, “Graphene nanomesh”, Nature Nanotechnology (2010) 5, 190. 
10.     J. W.  Bai, X. F. Duan, Y. Huang, “Rational fabrication of graphene nanoribbons with nanowire etch mask”, Nano Letters (2009) 9, 2083.
11.     J. W. Bai, S. Huang, L. Wang, Y. Chen, Y. Huang, “Fluid assisted assembly of one-dimensional nanoparticle array inside inorganic nanotubes”, Journal of Materials Chemistry (2009) 19, 921. 
12.     J. W. Bai, Y. Qin, C. Jiang, L. M. Qi, “Polymer-controlled synthesis of silver nanobelts and hierarchical nanocolumns”, Chemistry of Materials (2007) 19, 3367.
13.     P. Pang, B. Ashcroft, W. Song, P. Zhang, S. Biswas, Q. Qing, J. Yang, R. Nemanich, J. W. Bai, J. Smith, K. Reuter, V. Balagurusamy, Y. Astier, G. Stolovitzky, S. Lindsay, “Fixed-gap Tunnel Junction for Reading DNA Nucleotides”, ACS Nano (2014), 8, 11994. 
14.     B. Luan, J. W. Bai, G. Stolovitzky, “Fabricatable nanopore sensors with an atomic thickness”, Applied Physics Letters (2013), 103, 183501. 
15.     L. Liao, J. W. Bai, R. Cheng, H. L. Zhou, L. X. Liu, Y. Liu, Y. Huang, X. F. Duan, “Scalable fabrication of self-aligned graphene transistors and circuits on glass”, Nano Letters (2012), 12, 2653. 
16.     Z. Zhong, H. Zhang, Y. Liu, J. W. Bai, L. Liao, Y. Huang, X. F. Duan, “High-capacity silicon-air battery in alkaline solution”, Chemsuschem (2012), 5, 177. L. Liu, H. Zhou, R. Cheng, Y. Chen, Y.-C. Lin, Y. Qu, J. W. Bai, I. A. Ivanov, G. Liu, Y. Huang, X. F. Duan, “A systematic study of atmospheric pressure chemical vapor deposition growth of large area monolayer graphene”, Journal of Materials Chemistry (2012), 22, 1498. 
17.     Y. Liu, R. Cheng, L. Liao, H. Zhou, J. W. Bai, G. Liu, L. Liu, Y. Huang, X. F. Duan, “Plasmon resonance enhanced multicolour photodetection by graphene”, Nature Communication (2011), 2, 579. 
18.     G. Xu, C. M. Torres, J. W. Bai, J. Tang, T. Yu, Y. Huang, X. F. Duan, Y. Zhang, K. L. Wang, “Linewidth roughness in nanowire-mask-based graphene nanoribbons”, Applied Physics Letters (2011), 98, 243118. 
19.     Y. Qu, J. W. Bai, L. Liao, R. Cheng, Y.C. Lin, Y. Huang, T. Guo, X. F. Duan, “Synthesis and electric properties of dicobalt silicide nanobelts”, Chemical Communications  (2011), 47, 1255.
20.     G. Xu, C. M. Torres, J. Tang, J. W.  Bai, E. Song, Y. Huang, X. F. Duan, Y. Zhang, K. L. Wang, “Edge effect on resistance scaling rules in graphene nanostructures”, Nano Letters (2011) 11, 1082. 
21.     L. Liao, Y. C. Lin, M. Bao, R. Cheng, J. W. Bai, Y. Liu, K. L. Wang, Y. Huang, X. F. Duan, “High speed graphene transistor with a self-aligned nanowire gate”, Nature (2010) 467, 305.

    部分專利    
 
  1. 中國(guó)專利 一種形成薄膜的方法和應(yīng)用,2021,CN109338598B;

  2. 美國(guó)專利Compositions and methods for single molecular placement on a substrate,2019,US10350570B;

  3. 美國(guó)專利 Hybrid Nanopore Sensors,2019,US10519499B;

  4. 美國(guó)專利 Bichemically activated electronic device, 2020, US10545115B;

  5. 美國(guó)專利 Methods and arrays for producing and sequencing monoclonal clusters of nucleic acid, 2020, US10619204B。


聯(lián)系方式:

 
郵件:     jingwbai@mail.tsinghua.edu.cn;    
電話:010-62789815;    
地址:清華大學(xué)生物技術(shù)館3-209
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