1. 氮雜環(huán)卡賓有機(jī)不對(duì)稱催化對(duì)醛實(shí)現(xiàn)多位點(diǎn)、選擇性的官能化：以廉價(jià)易得的醛為基礎(chǔ)化工原料，實(shí)現(xiàn)多位點(diǎn)、選擇性的官能化是構(gòu)筑新穎手性片段最直接、高效的方法之一。同時(shí)這些片段是各種高附加值化學(xué)產(chǎn)品或藥物的前體，具有重要的商業(yè)價(jià)值。申請(qǐng)人通過(guò)改造卡賓催化劑立體結(jié)構(gòu)和電子效應(yīng)來(lái)調(diào)控反應(yīng)的化學(xué)、區(qū)域、以及立體選擇性；通過(guò)引入?yún)f(xié)同催化策略和發(fā)展合適的親電或親核試劑來(lái)優(yōu)化反應(yīng)的活化能,最終在醛的多個(gè)位置(鄰位、間位、遠(yuǎn)端的碳)實(shí)現(xiàn)了不對(duì)稱氟化、氫酰化、中環(huán)化、芳構(gòu)化等官能團(tuán)化反應(yīng)。重點(diǎn)突破了對(duì)富電子烯烴加成難得瓶頸,填補(bǔ)了卡賓高效、多樣性催化合成光學(xué)活性寡糖得空白; 發(fā)展了卡賓與路易斯酸或布朗斯特酸催化協(xié)同策略，為“卡賓催化實(shí)現(xiàn)遠(yuǎn)程立體控制”提供了解決思

路。 

 

2. 金屬參與的碳?xì)滏I催化活化實(shí)現(xiàn)雜環(huán)的高效合成：提出了基于金屬插入碳?xì)滏I活化的方式，結(jié)合炔作為搭建砌塊，高區(qū)域選擇性的合成了一些重要的雜環(huán)骨架，為多樣性合成基于該類優(yōu)勢(shì)核心結(jié)構(gòu)的先導(dǎo)化合物或雜環(huán)碎片提供了重要方法依據(jù)。

3. 通過(guò)高通量篩選，并對(duì)所發(fā)現(xiàn)的先導(dǎo)化合物進(jìn)行改造，成功了發(fā)現(xiàn)了能夠誘導(dǎo)胚胎干細(xì)胞定向分化和控制造血干細(xì)胞體外擴(kuò)增的Lead小分子。該兩個(gè)項(xiàng)目已經(jīng)分別進(jìn)入了不同的臨床實(shí)驗(yàn)階段，將對(duì)干細(xì)胞再生藥物的研究起到重要推動(dòng)作用。

4．基于“遺忘機(jī)制”開(kāi)發(fā)治療老年癡呆癥新藥：申請(qǐng)人團(tuán)隊(duì)與清華大學(xué)生命學(xué)院腦科學(xué)專家鐘毅教授團(tuán)隊(duì)聯(lián)合，結(jié)合多年對(duì)研究大腦所獲得的深入理解，另辟蹊徑，以遺忘機(jī)制作為研發(fā)老年癡呆癥疾病的全新突破口，通過(guò)確定遺忘分子，來(lái)開(kāi)發(fā)抑制加速遺忘的藥物，以期從記憶層面來(lái)改善老年癡呆疾病的新藥。目前老年癡呆（AD）新藥開(kāi)發(fā)（first-in-class類）獲得CDE審批,已經(jīng)在宣武,協(xié)和等醫(yī)院開(kāi)展臨床研究。

國(guó)家萬(wàn)人計(jì)劃領(lǐng)軍人才（2020）

科技部中青年創(chuàng)新科技人才（2020）

德國(guó)拜耳研究員（2015和2018）

湖北省自然科學(xué)二等獎(jiǎng)（2016）

OCF雜志特別研究員（Emerging Investigator）（2015）

歐洲雜志Natural Products Against Cancer主編（2012-2014）

Asia Core Program Lectureship（日本，2013）

新加坡國(guó)立大學(xué)(NUS) Assistant Professorship(2009)

新加坡南洋理工大學(xué)(NTU) Nanyang Assistant Professorship(2009)

1.Li, L. Y.; Wang, X.; Gao, R.; Zhang, B.; Liu, Y.; Zhou, J.; Fu, L.; Wang, J*; Inflammation-Triggered Supramolecular Nanoplatform for Local Dynamic Dependent Imaging-Guided Therapy of Rheumatoid Arthritis，Adv. Sci., 2022, 2105188.

2.Peng, Q.; Yan, B..; Li, F.; Lang, M.; Zhang, B.; Guo, D.; Bierer, D.; Wang, J*; Biomimetic Enantioselective Synthesis of β,β-Difluoro-α-amino Acid Derivatives，Commun. Chem., 2021, 4, 148.

3.Li, L.; Zhang, B.; Liu, Y.; Gao, R.; Zhou, J.; Fu, L.; Wang, J*; A Spontaneous Membrane-Adsorption Approach to Enhancing Second Near-Infrared Deep-Imaging-Guided Intracranial Tumor Therapy，ACS Nano, 2021, 15, 4518.

4.Yang, G. M.; Guo, D. H.; Meng, D.; Wang, J*; NHC-catalyzed Atropoenantioselective Synthesis of Axially Chiral Biaryl Amino Alcohols via a Cooperative Strategy，Nature Commun., 2019, 10, 3062.

5.Zhao, C. G；Guo, D. H.; Munkerup, K.; Huang, K. W.； Li， F. Y.; Wang, J*; Enantioselective [3+3] Atroposelective Annulation Catalyzed by N-heterocyclic Carbenes，Nature Commun., 2018, 9, 611.

6.Peng， Q. P.; Guo, D. H.; Bie, J. B.; Wang, J*; Catalytic Enantioselective Aza‐Benzoin Reactions of Aldehydes with 2H‐Azirines, Angew. Chem. Int. Ed., 2018, 57, 3761.

7.Zhang, J. W.; Wang, J*; Atropoenantioselective Redox‐Neutral Amination of Biaryl Compounds through Borrowing Hydrogen and Dynamic Kinetic Resolution, Angew. Chem. Int. Ed., 2018, 57, 465.

8.Wu, Z. J.; Wang, J*; A Tandem Dearomatization/Rearomatization Strategy: Enantioselective N-Heterocyclic Carbene-Catalyzed α-Arylation, Chem. Sci., 2019, 10, 2501.

9.Wu, J. C.; Zhao, C. G.; Wang, J*; Enantioselective Intermolecular Enamide-Aldehyde Cross-Coupling Catalyzed by Chiral N-Heterocyclic Carbenes, J. Am. Chem. Soc., 2016, 138, 4706.

2. Zhao, C. G.; Li, F. Y.; Wang, J*; N-heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones, Angew. Chem. Int. Ed., 2016, 55, 1820.

10.Zhao, C. G.; Li, F. Y.; Wang, J*; N-heterocyclic Carbene Catalyzed Dynamic Kinetic Resolution of Pyranones, Angew. Chem. Int. Ed., 2016, 55, 1820.

11.Wu, J. C.; Xu, W. B.; Yu, Z.-X.*; Wang, J*; Ruthenium-catalyzed Formal Dehydrative [4 + 2] Cycloaddition of Enamides and Alkynes for the Synthesis of Highly Substituted Pyridines: Reaction Development and Mechanistic Study, J. Am. Chem. Soc., 2015, 137, 9489.

12.Wu, Z. J.; Li, F. Y.; Wang, J*; Intermolecular Dynamic Kinetic Resolution Cooperatively Catalyzed by an N-Heterocyclic Carbene and a Lewis Acid, Angew. Chem. Int. Ed., 2015, 54, 1629.

13.Li, F. Y.; Wu, Z. J.; Wang, J*; Oxidative Enantioselective α-Fluorination of Aliphatic Aldehydes Enabled by N-Heterocyclic Carbene Catalysis, Angew. Chem. Int. Ed., 2015, 54, 656.

14.Li, W. J.; Wang, J*; Lewis Base Catalyzed Aerobic Oxidative Intermolecular Azide-Zwitterion Cycloaddition, Angew. Chem. Int. Ed., 2014, 53, 14186.

15.Wang, L.; Huang, J. Y.; Liu, H.; Peng, S. Y.; Jiang, X.-F.*; Wang, J.* Palladium-catalyzed Oxidative Cycloaddition via C–H/N–H Activation: Access to Benzazepines, Angew. Chem. Int. Ed., 2013, 52, 1768.

16.Boitano, A. E.; Wang, J.; Romeo, R.; Bouchez, L. G.; Parker, A. E; Sutton, S. U.; Walker, J. R.; Flaveny, C. A.; Perdew, G. H; Denison, M. S.; Schultz, P. G., Cooke, M. P. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells, Science 2010, 329, 1345-1348.

17.Zhu, S. T.; Wurdak, H.; Wang, J.; Lyssiotis, C. A.; Peters, E. C.; Cho, C. Y.; Wu, X.; Schultz, P. G. A Small Molecule Primes Embryonic Stem Cells for Differentiation, Cell Stem Cell, 2009, 4(5), 416-426.

18.Wang, J.; Xie, H.-X.; Li, H.; Zu, L.-S.; Wang, W. A Highly Stereoselective Hydrogen-Bond-Mediated Michael-Michael Cascade Process through Dynamic Kinetic Resolution, Angew. Chem. Int. Ed., 2008, 47, 4177.

19.Wang, J.; Li, H.; Zu, L.-S.; Wang, W. Organcatalytic Enantioselective Conjugate Additions to Enones, J. Am. Chem. Soc., 2006, 128, 12652.

20.Wang, J.; Li, H.; Xie, H.-X.; Zu, L.-S.; Shen, X.; Wang, W. Organocatalytic Enantioselective Cascade Michael-Aldol Condensation Reactions: Efficient Assembly of Densely Functionalized Chiral Cyclopentenes, Angew. Chem. Int. Ed., 2007, 46, 9050.

21.Wang, J.; Li, H.; Wang, W.; Direct, Highly Enantioselective Pyrrolidine Sulfonamide Catalyzed Michael Addition Reactions of Aldehydes to Nitrostyrenes, Angew. Chem. Int. Ed., 2005, 44, 1369.

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